Find out who is missing through injury, who’s in a race against time to prove their fitness and who has been ruled out through suspension for the next round of Premier League fixtures.
And as you plan your fantasy team for the next gameweek, check out the Expected XIs for all 20 clubs.
Positions: Goalkeeper (GK), Defender (D), Left-back (LB), Right-back (RB), Centre-back (CB), Midfielder (M), Defensive midfield (DM), Central midfield (CM), Left midfield (LM), Right midfield (RM), Attacking midfield (AM), Left winger (LW), Right winger (RW), Forward (F), Left forward (FWL), Right forward (FWR), Striker (ST)
(All Expected XIs and injury news powered by Rotowire, subject to updates.)
Everton v Wolverhampton Wanderers
Goodison Park
Wednesday, 7.30 p.m. GMT / 2.30 p.m. ET
Latest Everton team news
Expected Lineup:
GK Jordan Pickford
LB Vitaliy Mykolenko | CB Jarrad Branthwaite | CB James Tarkowski | RB Ashley Young
DM Abdoulaye Doucouré | DM Idrissa Gueye
LW Iliman Ndiaye | AM Dwight McNeil | RW Jack Harrison
ST Dominic Calvert-Lewin
Injury/suspension updates:
Armando Broja, F, ankle, DOUBT
James Garner, M, back, OUT, estimated return Dec. 29
Tim Iroegbunam, M, foot, OUT, estimated return Dec. 29
Youssef Chermiti, F, foot, OUT, estimated return Dec. 26
Latest Wolverhampton Wanderers team news
Expected Lineup:
GK José Sá
LB Rayan Aït-Nouri | CB Craig Dawson | CB Toti Gomes | RB Matt Doherty
DM João Gomes | DM Mario Lemina
LW Matheus Cunha | AM Pablo Sarabia | RW Goncalo Guedes
ST Jørgen Strand Larsen
Injury/suspension updates:
Enso Gonzalez, F/M, knee, OUT, estimated return May. 3
Sasa Kalajdzic, F, knee, OUT, estimated return Jan. 15
Yerson Mosquera, D, knee, OUT, estimated return Aug. 15
Nélson Semedo, M/D, suspension, due back Dec. 9
Boubacar Traoré, M, knee, OUT, estimated return Jan. 15
Manchester City v Nottingham Forest
Etihad Stadium
Wednesday, 7.30 p.m. GMT / 2.30 p.m. ET
Latest Manchester City team news
Expected Lineup:
GK Ederson
LB Josko Gvardiol | CB Manuel Akanji | CB Rúben Dias | RB Rico Lewis
DM Bernardo Silva | DM Matheus Nunes
LW Jack Grealish | AM Kevin De Bruyne | RW Jérémy Doku
ST Erling Haaland
Injury/suspension updates:
Oscar Bobb, F/M, leg, OUT, estimated return Jan. 14
Rodri, M, knee, OUT, estimated return Jul. 1
Mateo Kovacic, M, undisclosed, OUT, estimated return Dec. 15
John Stones, D, foot, OUT, estimated return Dec. 7
Latest Nottingham Forest team news
Expected Lineup:
GK Matz Sels
LB Neco Williams | CB Murillo | CB Nikola Milenkovic | RB Ola Aina
DM Nicolás Domínguez | DM Ryan Yates
LW Callum Hudson-Odoi | AM Morgan Gibbs-White | RW Anthony Elanga
ST Chris Wood
Injury/suspension updates:
Danilo Oliveira, M, ankle, OUT, estimated return Dec. 21
Ibrahim Sangaré, M, thigh, OUT, estimated return Jan. 25
Newcastle United v Liverpool
St. James’ Park
Wednesday, 7.30 p.m. GMT / 2.30 p.m. ET
Latest Newcastle United team news
Expected Lineup:
GK Nick Pope
LB Lewis Hall | CB Dan Burn | CB Fabian Schär | RB Valentino Livramento
CM Joelinton | CM Bruno Guimaraes | CM Sean Longstaff
FWL Anthony Gordon | ST Alexander Isak | FWR Jacob Murphy
Injury/suspension updates:
Sven Botman, D, knee, DOUBT
Alexander Isak, F, hip, DOUBT
Emil Krafth, D, collarbone, OUT, estimated return Jan. 4
Jamaal Lascelles, D, knee, OUT, estimated return Jan. 15
Latest Liverpool team news
Expected Lineup:
GK Caoimhín Kelleher
LB Andrew Robertson | CB Joe Gomez | CB Virgil van Dijk | RB Trent Alexander-Arnold
DM Ryan Gravenberch | DM Alexis Mac Allister
LW Cody Gakpo | AM Curtis Jones | RW Mohamed Salah
ST Darwin Núñez
Injury/suspension updates:
Alisson Becker, G, hamstring, OUT, estimated return Dec. 7
Conor Bradley, D, hamstring, OUT, estimated return Dec. 29
Federico Chiesa, F/M, undisclosed, OUT, estimated return Dec. 7
Diogo Jota, F, upper body, OUT, estimated return Dec. 7
Ibrahima Konaté, D, foot, OUT, estimated return Dec. 29
Kostas Tsimikas, D, ankle, OUT, estimated return Dec. 7
Southampton v Chelsea
St. Mary’s Stadium
Wednesday, 7.30 p.m. GMT / 2.30 p.m. ET
Latest Southampton team news
Expected Lineup:
GK Joe Lumley
LB Ryan Manning | CB Jan Bednarek | CB Jack Stephens | CB Kyle Walker-Peters | RB Yukinari Sugawara
CM Joe Aribo | CM Ryan Fraser | CM Mateus Fernandes
ST Adam Armstrong | ST Paul Onuachu
Injury/suspension updates:
Gavin Bazunu, G, achilles, OUT, estimated return Jan. 11
Jan Bednarek, D, knee, DOUBT
Tyler Dibling, M, suspension, due back Dec. 7
Flynn Downes, M, suspension, due back Dec. 7
Taylor Harwood-Bellis, D, suspension, due back Dec. 7
Adam Lallana, M, hamstring, OUT, estimated return Dec. 15
Paul Onuachu, F, undisclosed, DOUBT
Aaron Ramsdale, G, finger, OUT, estimated return Dec. 15
William Smallbone, M, hamstring, OUT, estimated return Dec. 15
Ross Stewart, F, calf, OUT, estimated return Dec. 7
Lesley Ugochukwu, M, not injury related, OUT, estimated return Dec. 7
Latest Chelsea team news
Expected Lineup:
GK Robert Sánchez
LB Marc Cucurella | CB Tosin Adarabioyo | CB Levi Colwill | RB Malo Gusto
DM Moisés Caicedo | DM Enzo Fernández
LW João Félix | AM Cole Palmer | RW Noni Madueke
ST Nicolas Jackson
Injury/suspension updates:
Wesley Fofana, D, hamstring, OUT, estimated return Dec. 22
Reece James, D, hamstring, OUT, estimated return Jan. 4
Arsenal v Manchester United
Emirates Stadium
Wednesday, 8.15 p.m. GMT / 3.15 p.m. ET
Latest Arsenal team news
Expected Lineup:
GK David Raya
LB Riccardo Calafiori | CB Gabriel Magalhaes | CB William Saliba | RB Jurriën Timber
CM Martin Ødegaard | CM Mikel Merino | CM Declan Rice
FWL Gabriel Martinelli | ST Kai Havertz | FWR Bukayo Saka
Injury/suspension updates:
Riccardo Calafiori, D, undisclosed, DOUBT
Gabriel Magalhaes, D, undisclosed, DOUBT
Mikel Merino, M, knee, DOUBT
Thomas Partey, M/D, strain, DOUBT
Takehiro Tomiyasu, D, knee, OUT, estimated return Dec. 8
Ben White, D, knee, OUT, estimated return Jan. 15
Latest Manchester United team news
Expected Lineup:
GK André Onana
CB Matthijs de Ligt | CB Harry Maguire | CB Noussair Mazraoui
LM Diogo Dalot | CM Mason Mount | CM Manuel Ugarte | RM Amad Diallo
AM Alejandro Garnacho | AM Bruno Fernandes
ST Rasmus Højlund
Injury/suspension updates:
Jonny Evans, D, undisclosed, OUT, estimated return Dec. 7
Victor Lindelöf, D, groin, OUT, estimated return Dec. 7
Kobbie Mainoo, M, suspension, due back Dec. 7
Lisandro Martínez, D, suspension, due back Dec. 7
Luke Shaw, D, strain, OUT, estimated return Dec. 22
Leny Yoro, D, foot, DOUBT
Aston Villa v Brentford
Villa Park
Wednesday, 8.15 p.m. GMT / 3.15 p.m. ET
Latest Aston Villa team news
Expected Lineup:
GK Robin Olsen
LB Ian Maatsen | CB Diego Carlos | CB Pau Torres | RB Ezri Konsa
DM Ross Barkley | DM Youri Tielemans
LW John McGinn | AM Morgan Rogers | RW Leon Bailey
ST Ollie Watkins
Injury/suspension updates:
Emiliano Martínez, G, wrist, DOUBT
Amadou Onana, M, undisclosed, OUT, estimated return Dec. 7
Jacob Ramsey, M, hamstring, OUT, estimated return Dec. 14
Latest Brentford team news
Expected Lineup:
GK Mark Flekken
LB Keane Lewis-Potter | CB Nathan Collins | CB Ethan Pinnock | RB Sepp van den Berg
DM Vitaly Janelt | DM Christian Nørgaard
LW Kevin Schade | AM Mikkel Damsgaard | RW Bryan Mbeumo
ST Yoane Wissa
Injury/suspension updates:
Kristoffer Ajer, D, foot, OUT, estimated return Dec. 7
Josh Dasilva, M, knee, OUT, estimated return Jan. 14
Rico Henry, M/D, knee, OUT, estimated return Dec. 7
Aaron Hickey, M/D, hamstring, OUT, estimated return May. 18
Mathias Jensen, M, hamstring, OUT, estimated return Dec. 7
Gustavo Nunes, F/M, back, OUT, estimated return Dec. 7
Fulham v Brighton & Hove Albion
Craven Cottage
Thursday, 7.30 p.m. GMT / 2.30 p.m. ET
Latest Fulham team news
Expected Lineup:
GK Bernd Leno
LB Antonee Robinson | CB Calvin Bassey | CB Issa Diop | RB Kenny Tete
DM Sander Berge | DM Andreas Pereira
LW Reiss Nelson | AM Emile Smith Rowe | RW Alex Iwobi
ST Raúl Jiménez
Injury/suspension updates:
Joachim Andersen, D, calf, OUT, estimated return Dec. 22
Tom Cairney, M, suspension, due back Dec. 22
Jorge Cuenca, D, undisclosed, DOUBT
Sasa Lukic, M, suspension, due back Dec. 8
Andreas Pereira, M, undisclosed, DOUBT
Harrison Reed, M, knee, OUT, estimated return Dec. 29
Carlos Vinícius, F, undisclosed, DOUBT
Latest Brighton & Hove Albion team news
Expected Lineup:
GK Bart Verbruggen
LB Pervis Estupiñán | CB Lewis Dunk | CB Jan Paul van Hecke | RB Tariq Lamptey
DM Carlos Baleba | DM Matt O’Riley
LW Kaoru Mitoma | AM João Pedro | RW Simon Adingra
ST Danny Welbeck
Injury/suspension updates:
Yasin Ayari, M, undisclosed, DOUBT
Brajan Gruda, F/M, illness, DOUBT
Jack Hinshelwood, M/D, knee, DOUBT
Ferdi Kadioglu, M/D, toe, DOUBT
Solly March, F/M, knee, OUT, estimated return Dec. 8
James Milner, M/D, hamstring, OUT, estimated return Dec. 8
Kaoru Mitoma, F/M, undisclosed, DOUBT
Joël Veltman, D, undisclosed, DOUBT
Adam Webster, D, hamstring, OUT, estimated return Dec. 8
AFC Bournemouth v Tottenham Hotspur
Vitality Stadium
Thursday, 8.15 p.m. GMT / 3.15 p.m. ET
Latest AFC Bournemouth team news
Expected Lineup:
GK Kepa Arrizabalaga
LB Milos Kerkez | CB Dean Huijsen | CB Illia Zabarnyi | RB Adam Smith
DM Tyler Adams | DM Ryan Christie
LW Marcus Tavernier | AM Justin Kluivert | RW Antoine Semenyo
ST Evanilson
Injury/suspension updates:
Julián Araujo, D, hamstring, OUT, estimated return Feb. 25
Lewis Cook, M, undisclosed, DOUBT
Alex Scott, M, knee, OUT, estimated return Dec. 21
Luis Sinisterra, F/M, hamstring, DOUBT
Latest Tottenham Hotspur team news
Expected Lineup:
GK Fraser Forster
LB Destiny Udogie | CB Ben Davies | CB Radu Dragusin | RB Pedro Porro
CM James Maddison | CM Yves Bissouma | CM Pape Matar Sarr
FWL Son Heung-Min | ST Dominic Solanke | FWR Dejan Kulusevski
Injury/suspension updates:
Rodrigo Bentancur, M, suspension, due back Dec. 26
Richarlison, F, hamstring, OUT, estimated return Dec. 15
Archie Gray, M/D, leg, DOUBT
Mikey Moore, F/M, illness, OUT, estimated return Dec. 12
Wilson Odobert, F/M, hamstring, OUT, estimated return Feb. 15
Cristian Romero, D, foot, DOUBT
Dominic Solanke, F, illness, DOUBT
Micky van de Ven, D, hamstring, OUT, estimated return Dec. 26
Guglielmo Vicario, G, ankle, OUT, estimated return Feb. 25